INDICATIONS AND DOSING INFORMATION

Aspirin is indicated:

  1. To reduce the combined risk of death and nonfatal stroke in patients who have had ischemic stroke or transient ischemia of the brain due to fibrin platelet emboli
  2. To reduce the risk of vascular mortality in patients with a suspected acute myocardial infarction (MI)
  3. To reduce the combined risk of death and nonfatal MI in patients with a previous MI or unstable angina pectoris
  4. To reduce the combined risk of MI and sudden death in patients with chronic stable angina pectoris
  5. In patients who have undergone revascularization procedures (ie, coronary artery bypass graft [CABG], percutaneous transluminal coronary angioplasty [PTCA], or carotid endarterectomy [CEA]) when there is a preexisting condition for which aspirin is already indicated
  6. For the relief of the signs and symptoms of rheumatoid arthritis, juvenile rheumatoid arthritis, osteoarthritis, spondyloarthropathies, and arthritis and pleurisy associated with systemic lupus erythematosus.

Each dose of aspirin should be taken with a full glass of water, unless patient is fluid restricted. Anti-inflammatory and analgesic dosages should be individualized. When aspirin is used in high doses, the development of tinnitus may be used as a clinical sign of elevated plasma salicylate levels except in patients with high frequency hearing loss.

Ischemic Stroke and Transient Ischemic Attack

50-325 mg once a day. Continue therapy indefinitely.

Suspected Acute MI

The initial dose of 160-162.5 mg is administered as soon as an MI is suspected. The maintenance dose of 160-162.5 mg a day is continued for 30 days post-infarction. After 30 days, consider further therapy based on dosage and administration for prevention of recurrent MI.

Prevention of Recurrent MI

75-325 mg once a day. Continue therapy indefinitely.

Unstable Angina Pectoris

75-325 mg once a day. Continue therapy indefinitely.

Chronic Stable Angina Pectoris

75-325 mg once a day. Continue therapy indefinitely.

CABG

325 mg daily starting 6 hours post-procedure. Continue therapy for one year post-procedure.

PTCA

The initial dose of 325 mg should be given 2 hours pre-surgery. Maintenance dose is 160-325 mg daily. Continue therapy indefinitely.

Carotid Endarterectomy

Doses of 80 mg once daily to 650 mg twice daily, started pre-surgery, are recommended. Continue therapy indefinitely.